Set in the small coastal town of Bright Leaf, North Carolina, “Pieces of Talent” centers around Charlotte, a disillusioned aspiring actress working a night job as a cocktail waitress in order to make ends meet. Charlotte catches a break when seemingly chance circumstances put her in contact with a local filmmaker, David Long. David and Charlotte form a quick friendship that leads to Charlotte landing the starring role in David’s newest project. David quickly becomes obsessed with Charlotte and begins building his masterpiece. He films each encounter with the ultimate goal of filming Charlotte as his final installment. David is a happily obsessed individual willing to do whatever it takes to make “true art.” He utilizes his charm and skills to make something dark and deranged seem utterly beautiful and loving.
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Figure 1 . Comparison between healthy (A) and cancer (B) cells: circadian and metabolic differences in NADPH cellular handling. In both entities, there is a dual interaction between the transcriptional and the redox circadian clocks. However, in cancerous cells, the daily variations in biochemical and molecular phenomena are disrupted. A major difference between a normal and a transformed cancer cell is the bioenergetic adaptation in which the main mitochondrial activity is no longer ATP production (glycolysis/oxidative phosphorylation en healthy cells) but the constant input of metabolic intermediaries (Warburg effect, or aerobic glycolysis, in cancerous cells) that are needed for cellular duplication. A distinctive biochemical characteristic in carcinogenesis is the increased availability of the anabolic coenzyme, NADPH; NADPH can be potentially be formed by various enzymatic reactions. Regarding the higher levels of NADPH, the production of acetyl-CoA (AcCoA) is also increased by the activity of the cytoplasmic enzyme citrate lyase. In the figure, events or enzymatic reactions that show circadian rhythmicity are depicted by the symbol ~; for example, circadian rhythmicity of the pentose phosphate pathway (PPP) in normal cells. Question marks ( ? ) indicate events or enzymatic reactions that have not been characterized as showing putative daily rhythmicity in either healthy or cancer cells.