If you decide it makes sense to get vaccinated against the flu, then it also makes sense to get vaccinated each year. Unless your circumstances change dramatically, if catching the flu is not an acceptable risk for you this year, why would it be so next year? Bear in mind your chances of catching the flu are a handful of times in a lifetime – so only by getting the flu shot every year for a significant number of years do you get to reap the benefits. You can’t know in advance which year the nasty virus will try to crawl into your lap.
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.