Homodimer steroid receptor

steroid-binding site     sex steroid     shbg homodimer     single amino acid substitution     site-directed mutagenesis     human shbg     aminoterminal laminin g-like domain     homodimeric complex     human sex hormone-binding globulin     single steroid-binding site     prevailing assumption     shbg variant     dimer interface     dimerization domain     little information     crystallographic analysis     steroid binding stoichiometry     crystallographic model     homodimeric shbg molecule    

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Sex hormone-binding globulin (SHBG) is thought to mainly function as a transporter and reservoir for the estradiol and testosterone sex hormones. However it has also been demonstrated that SHBG can bind to a cell surface receptor (SHBG-R). The SHBG-R has not been completely characterized. A subset of steroids are able to bind to the SHBG/SHBG-R complex resulting in an activation of adenylyl cyclase and synthesis of the cAMP second messenger. [19] Hence the SHBG/SHBG-R complex appears to act as a transmembrane steroid receptor that is capable of transmitting signals to the interior of cells.

Homodimer steroid receptor

homodimer steroid receptor


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