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While both androsterone and epiandrosterone may be used as a capsule, androsterone may be more powerful when used as a sublingual (where it is absorbed through the tissues under the tongue directly into the blood stream) and epiandrosterone looks promising to use as a transdermal (where it is applied to and absorbed through the skin). For this reason, androsterone products are often sold as a lozenge to be dissolved slowly in the mouth. The typical dosage range for androsterone is 300-400 mg/day, though some may dose higher. This is best used in 4-6 week cycles, with a mild over the counter post-cycle therapy to follow such as an all-in-one test booster and estrogen blocker, of which there are many to choose from.
During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.