NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.
Humira became the first and only FDA-approved non-steroid treatment for noninfectious uveitis in June 2016. This is an important advance in the treatment of noninfectious uveitis because long-term steroid use often leads to cataracts and glaucoma in uveitis patients. Because Humira doesn’t have the same side effects as steroids, it can be safely used to control the chronic inflammation associated with uveitis.
“The goal of the clinical trial was to determine whether Humira is a safe and effective alternative that could replace or minimize the use of steroids,” Dr. Jaffe said. “There are pros and cons to all of the treatments that we use, so we always need to reach a balance. And because uveitis is not just one, but rather a group of several different diseases, treatment must be highly individualized—not only by disease type and severity, but also with regard to the patient’s other health factors.”