Since the start of the AIDS epidemic, PCP has been closely associated with AIDS. Because it only occurs in an immunocompromised host, it may be the first clue to a new AIDS diagnosis if the patient has no other reason to be immunocompromised (. taking immunosuppressive drugs for organ transplant ). An unusual rise in the number of PCP cases in North America, noticed when physicians began requesting large quantities of the rarely used antibiotic pentamidine , was the first clue to the existence of AIDS in the early 1980s.  
Trimetrexate (Neutrexin) is a significantly more potent inhibitor of DHFR than trimethoprim (Proloprim), 18 so potent that hematopoietic cells must be protected through the coadministration of leucovorin. Although trimetrexate is significantly less toxic than trimethoprim-sulfamethoxazole, it is also less effective. 21 Because it is administered once daily, trimetrexate can be used in outpatients even though it is given intravenously. To mimic the sequential enzyme blockade provided by trimethoprim-sulfamethoxazole, dapsone (100 mg orally) can be added to the regimen.
I do have insurance, work full time, have for all of my adult life. And, I can’t afford the care of my own freaking teeth!! Whether you have insurance or not, it is a fortune. The health care industry is in crisis, never in older generations did people have to pay so much for health and dental insurance and STILL have to pay a fortune out of pocket and for prescriptions that are expensive. Its what happens when something as important as health care is left to the wolves of capitalism, as is the way of so many of our systems over the last few generations. I would give anything for SOCIALIZED HEALTH AND DENTAL CARE RIGHT NOW. We live in a world where we have to be insured for everything – this is progress?!?!
Have a nice day – and by the way – we were all immigrants to this country unless you are a native american, which I’m guessing you’re not.